ea0040l3 | Telomerase promoter mutations in cancer: beyond immortalization? | ESEBEC2016
Soares Paula
, Biology Group Cancer
Cell immortalization has been considered for a long time as a classic hallmark of cancer cells. Besides telomere maintenance due to the alternative mechanism of telomere lengthening it was advanced that such immortalization could be due to telomerase reactivation, but the mechanisms underlying such reactivation remained elusive.Mutations in the coding region of telomerase gene are very rare in the cancer setting, despite being associated with...